abstract：BACKGROUND:Recent studies clearly suggest that regulatory T cells play a critical role in the control of the immunoinflammatory response in atherosclerosis and substantially limit lesion development. Measles virus infection or vaccination is associated with immune depression, in part through the induction of an antiinf...

journal_title：Circulation

authors： Ait-Oufella H,Horvat B,Kerdiles Y,Herbin O,Gourdy P,Khallou-Laschet J,Merval R,Esposito B,Tedgui A,Mallat Z

更新日期：2007-10-09 00:00:00

abstract：BACKGROUND:The development of selective atrial antiarrhythmic agents is a current strategy for suppression of atrial fibrillation (AF). METHODS AND RESULTS:Whole-cell patch clamp techniques were used to evaluate inactivation of peak sodium channel current (I(Na)) in myocytes isolated from canine atria and ventricles. ...

journal_title：Circulation

authors： Burashnikov A,Di Diego JM,Zygmunt AC,Belardinelli L,Antzelevitch C

更新日期：2007-09-25 00:00:00

abstract：BACKGROUND:Elevated asymmetrical dimethylarginine (ADMA) is a novel risk factor for atherosclerosis that may impair endothelial function by interfering with endothelial nitric oxide synthesis. To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachia...

journal_title：Circulation

authors： Juonala M,Viikari JS,Alfthan G,Marniemi J,Kähönen M,Taittonen L,Laitinen T,Raitakari OT

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Aortic valve calcification is an actively regulated process that displays hallmarks of atherosclerosis. Natriuretic peptides (A-, B-, and C-type natriuretic peptides [ANP, BNP, and CNP]) have been reported to have a role in the pathogenesis of vascular atherosclerosis, but their expression in aortic valves i...

journal_title：Circulation

authors： Peltonen TO,Taskinen P,Soini Y,Rysä J,Ronkainen J,Ohtonen P,Satta J,Juvonen T,Ruskoaho H,Leskinen H

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:We investigated the feasibility and efficacy of polyethylenimine (PEI) based human vascular endothelial growth factor-165 (hVEGF165) gene transfer into human skeletal myoblasts (HSM) for cell based delivery to the infarcted myocardium. METHODS AND RESULTS:Based on optimized transfection procedure using enha...

journal_title：Circulation

authors： Ye L,Haider HKh,Tan R,Toh W,Law PK,Tan W,Su L,Zhang W,Ge R,Zhang Y,Lim Y,Sim EK

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:There is an elevated risk for poor outcomes after heart transplant (HTx) in patients sensitized to human leukocyte antigens including graft dysfunction, acute cellular and antibody-mediated (AMR) rejection, and cardiac allograft vasculopathy. We report our experience with human leukocyte antigens-sensitized ...

journal_title：Circulation

authors： Pollock-BarZiv SM,den Hollander N,Ngan BY,Kantor P,McCrindle B,West LJ,Dipchand AI

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Granulocyte-colony stimulating factor (G-CSF) after myocardial infarction does not affect systolic function when compared with placebo. In contrast, intracoronary infusion of bone marrow cells appears to improve ejection fraction. We aimed to evaluate the G-CSF mobilization of subsets of stem cells. METHODS...

journal_title：Circulation

authors： Ripa RS,Haack-Sørensen M,Wang Y,Jørgensen E,Mortensen S,Bindslev L,Friis T,Kastrup J

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Several centers favor replacing a diseased native heart valve with a tissue rather than a mechanical prosthesis, even in younger adult patients. However, long-term data supporting this approach are lacking. We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial ...

journal_title：Circulation

authors： Ruel M,Chan V,Bédard P,Kulik A,Ressler L,Lam BK,Rubens FD,Goldstein W,Hendry PJ,Masters RG,Mesana TG

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Continuous-flow rotary pumps with axial design are increasingly used for left ventricular assist support. The efficacy of this design compared with pulsatile, volume displacement pumps, with respect to characteristics of left ventricular unloading, and exercise performance remains largely unstudied. METHODS...

journal_title：Circulation

authors： Haft J,Armstrong W,Dyke DB,Aaronson KD,Koelling TM,Farrar DJ,Pagani FD

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...

journal_title：Circulation

authors： Tabereaux PB,Walcott GP,Rogers JM,Kim J,Dosdall DJ,Robertson PG,Killingsworth CR,Smith WM,Ideker RE

更新日期：2007-09-04 00:00:00

abstract：BACKGROUND:It is not known whether progression of aortic arch (AA) atheroma is associated with vascular events in patients with stroke or transient ischemic attack (TIA). METHODS AND RESULTS:AA atheroma was detected on baseline transesophageal echocardiogram in 167 consecutive patients who had prevalent stroke or TIA....

journal_title：Circulation

authors： Sen S,Hinderliter A,Sen PK,Simmons J,Beck J,Offenbacher S,Ohman EM,Oppenheimer SM

更新日期：2007-08-21 00:00:00

abstract：:Since the discovery that neuregulin-1 (NRG-1)/ErbB signaling is indispensable in cardiac development, evidence has shown that this system also plays a crucial role in the adult heart. In patients, an inhibitory ErbB2 antibody, trastuzumab, used in the treatment of mammary carcinomas, increases the risk for the develop...

journal_title：Circulation

authors： Lemmens K,Doggen K,De Keulenaer GW

更新日期：2007-08-21 00:00:00

abstract：BACKGROUND:In individuals without known cardiovascular disease, elevated body mass index (BMI) (weight/height2) is associated with an increased risk of death. However, in patients with certain specific chronic diseases, including heart failure, low BMI has been associated with increased mortality. METHODS AND RESULTS:...

journal_title：Circulation

authors： Kenchaiah S,Pocock SJ,Wang D,Finn PV,Zornoff LA,Skali H,Pfeffer MA,Yusuf S,Swedberg K,Michelson EL,Granger CB,McMurray JJ,Solomon SD,CHARM Investigators.

更新日期：2007-08-07 00:00:00

abstract：BACKGROUND:Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly understood. METHODS AND RESULTS:We used a forward genetic screen in zebrafish to identify novel genes required for myocardial fu...

journal_title：Circulation

authors： Knöll R,Postel R,Wang J,Krätzner R,Hennecke G,Vacaru AM,Vakeel P,Schubert C,Murthy K,Rana BK,Kube D,Knöll G,Schäfer K,Hayashi T,Holm T,Kimura A,Schork N,Toliat MR,Nürnberg P,Schultheiss HP,Schaper W,Schaper J,

更新日期：2007-07-31 00:00:00

abstract：BACKGROUND:The role of endothelial nitric oxide synthase (eNOS) in ischemic preconditioning (PC) and cardioprotection is poorly understood. We addressed this issue using a genetic, rather than pharmacological, approach. METHODS AND RESULTS:In the nonpreconditioned state, eNOS-/- mice exhibited infarct sizes similar to...

journal_title：Circulation

authors： Xuan YT,Guo Y,Zhu Y,Wang OL,Rokosh G,Bolli R

更新日期：2007-07-31 00:00:00

abstract：BACKGROUND:The Doppler Substudy of the randomized, double-blind, placebo-controlled Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial aimed to investigate the effects of intracoronary infusion of bone marrow-derived progenitor cells (BMCs) on coronary blood...

journal_title：Circulation

authors： Erbs S,Linke A,Schächinger V,Assmus B,Thiele H,Diederich KW,Hoffmann C,Dimmeler S,Tonn T,Hambrecht R,Zeiher AM,Schuler G

更新日期：2007-07-24 00:00:00

abstract：BACKGROUND:L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. L-arginine supplementation improves vascular reactivity and functional capacity in peripheral arterial disease (PAD) in small, short-term studies. We aimed to determine the effects of long-term administration of L-arg...

journal_title：Circulation

authors： Wilson AM,Harada R,Nair N,Balasubramanian N,Cooke JP

更新日期：2007-07-10 00:00:00

abstract：BACKGROUND:Left ventricular wall motion (WM) abnormalities have recognized prognostic significance in patients with coronary or other heart diseases; however, whether abnormal WM predicts adverse events in adults without overt cardiovascular disease has not been assessed. Our objective was to determine whether echocard...

journal_title：Circulation

authors： Cicala S,de Simone G,Roman MJ,Best LG,Lee ET,Wang W,Welty TK,Galloway JM,Howard BV,Devereux RB

更新日期：2007-07-10 00:00:00

abstract：BACKGROUND:Consensus guidelines and hospital quality-of-care programs recommend that ST-elevation myocardial infarction patients achieve a door-to-balloon time of < or = 90 minutes. However, there are limited prospective data on specific measures to significantly reduce door-to-balloon time. METHODS AND RESULTS:We pro...

journal_title：Circulation

authors： Khot UN,Johnson ML,Ramsey C,Khot MB,Todd R,Shaikh SR,Berg WJ

更新日期：2007-07-03 00:00:00

abstract：:Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary art...

journal_title：Circulation

authors： Boudina S,Abel ED

更新日期：2007-06-26 00:00:00

abstract：BACKGROUND:We wished to test previous hypotheses that sex-related differences in mortality and morbidity may be due to differences in the cause of heart failure or in left ventricular ejection fraction (LVEF) by comparing fatal and nonfatal outcomes in women and men with heart failure and a broad spectrum of left ventr...

journal_title：Circulation

authors： O'Meara E,Clayton T,McEntegart MB,McMurray JJ,Piña IL,Granger CB,Ostergren J,Michelson EL,Solomon SD,Pocock S,Yusuf S,Swedberg K,Pfeffer MA,CHARM Investigators.

更新日期：2007-06-19 00:00:00

abstract：BACKGROUND:Arterial hypertension is a prime cause of morbidity and mortality in the general population. Pharmacological treatment has limitations resulting from drug side effects, costs, and patient compliance. Thus, we investigated whether traditional Chinese medicine acupuncture is able to lower blood pressure. METH...

journal_title：Circulation

authors： Flachskampf FA,Gallasch J,Gefeller O,Gan J,Mao J,Pfahlberg AB,Wortmann A,Klinghammer L,Pflederer W,Daniel WG

更新日期：2007-06-19 00:00:00

abstract：BACKGROUND:Although several loci for familial dilated cardiomyopathy (DCM) have been mapped, the origin of a large percentage of DCM remains unclear. Mdm2, a p53-negative regulator, protects cardiomyocytes from ischemic and reperfusion-induced cell death. Mdm4, a homolog of Mdm2, inhibits p53 activity in numerous cell ...

journal_title：Circulation

authors： Xiong S,Van Pelt CS,Elizondo-Fraire AC,Fernandez-Garcia B,Lozano G

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Beta-blockers improve clinical outcome when administered early after acute myocardial infarction. However, whether beta-blockers actually reduce the myocardial infarction size is still in dispute. Cardiac magnetic resonance imaging can accurately depict the left ventricular (LV) ischemic myocardium at risk (...

journal_title：Circulation

authors： Ibanez B,Prat-González S,Speidl WS,Vilahur G,Pinero A,Cimmino G,García MJ,Fuster V,Sanz J,Badimon JJ

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:A robotic catheter navigation system has been developed that provides a significant degree of freedom of catheter movement. This study examines the feasibility of synchronizing this robotic navigation system with electroanatomic mapping and 3-dimensional computed tomography imaging to perform view-synchroniz...

journal_title：Circulation

authors： Reddy VY,Neuzil P,Malchano ZJ,Vijaykumar R,Cury R,Abbara S,Weichet J,McPherson CD,Ruskin JN

更新日期：2007-05-29 00:00:00

abstract：BACKGROUND:Smoking is a major risk factor for cardiovascular events. One of the potential mechanisms may be related to both coronary endothelial dysfunction and increased inflammatory response. The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunct...

journal_title：Circulation

authors： Lavi S,Prasad A,Yang EH,Mathew V,Simari RD,Rihal CS,Lerman LO,Lerman A

更新日期：2007-05-22 00:00:00

abstract：BACKGROUND:Age is an important determinant of outcomes for patients with acute coronary syndromes (ACS); however, community practice reveals a disproportionately lower use of cardiovascular medications and invasive treatment even among elderly patients with ACS who would stand to benefit. Reasons include limited trial ...

journal_title：Circulation

authors： Alexander KP,Newby LK,Cannon CP,Armstrong PW,Gibler WB,Rich MW,Van de Werf F,White HD,Weaver WD,Naylor MD,Gore JM,Krumholz HM,Ohman EM,American Heart Association Council on Clinical Cardiology.,Society of Geriatric Cardiology

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) may create an ischemic substrate conducive to sudden death, but it remains unknown whether the extent of hypertrophy is associated with proportionally poorer perfusion reserve. Comparisons between magnitude of hypertrophy, impairment of perfusion...

journal_title：Circulation

authors： Petersen SE,Jerosch-Herold M,Hudsmith LE,Robson MD,Francis JM,Doll HA,Selvanayagam JB,Neubauer S,Watkins H

更新日期：2007-05-08 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a life-threatening disease, characterized by vascular smooth muscle cell hyperproliferation. The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation. METHODS AND RESULTS:We investigated the expres...

journal_title：Circulation

authors： Schermuly RT,Pullamsetti SS,Kwapiszewska G,Dumitrascu R,Tian X,Weissmann N,Ghofrani HA,Kaulen C,Dunkern T,Schudt C,Voswinckel R,Zhou J,Samidurai A,Klepetko W,Paddenberg R,Kummer W,Seeger W,Grimminger F

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy has emerged as an important therapy for advanced systolic heart failure. Among available cardiac resynchronization therapy pacing modes that restore ventricular synchrony, it is uncertain whether simultaneous biventricular (BiV), sequential BiV, or left ventricular (LV) paci...

journal_title：Circulation

authors： Rao RK,Kumar UN,Schafer J,Viloria E,De Lurgio D,Foster E

更新日期：2007-04-24 00:00:00

abstract：BACKGROUND:Current diagnostic thresholds for ambulatory blood pressure (ABP) mainly rely on statistical parameters derived from reference populations. We determined an outcome-driven reference frame for ABP measurement. METHODS AND RESULTS:We performed 24-hour ABP monitoring in 5682 participants (mean age 59.0 years; ...

journal_title：Circulation

authors： Kikuya M,Hansen TW,Thijs L,Björklund-Bodegård K,Kuznetsova T,Ohkubo T,Richart T,Torp-Pedersen C,Lind L,Ibsen H,Imai Y,Staessen JA,International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcom

更新日期：2007-04-24 00:00:00

abstract：BACKGROUND:The extent of the peri-infarct zone by magnetic resonance imaging (MRI) has been related to all-cause mortality in patients with coronary artery disease. This relationship may result from arrhythmogenesis in the infarct border. However, the relationship between tissue heterogeneity in the infarct periphery a...

journal_title：Circulation

authors： Schmidt A,Azevedo CF,Cheng A,Gupta SN,Bluemke DA,Foo TK,Gerstenblith G,Weiss RG,Marbán E,Tomaselli GF,Lima JA,Wu KC

更新日期：2007-04-17 00:00:00

abstract：BACKGROUND:Erythropoietin (Epo) receptors (EpoRs) are expressed in the heart. We have recently demonstrated that the endogenous Epo-EpoR system plays an important protective role in myocardial ischemia in mice and humans. In the present study, we tested our hypothesis that the endogenous Epo-EpoR system in nonhematopoi...

journal_title：Circulation

authors： Asaumi Y,Kagaya Y,Takeda M,Yamaguchi N,Tada H,Ito K,Ohta J,Shiroto T,Shirato K,Minegishi N,Shimokawa H

更新日期：2007-04-17 00:00:00

abstract：BACKGROUND:The role of valve surgery in left-sided infective endocarditis has not been evaluated in randomized controlled trials. We examined the association between valve surgery and all-cause 6-month mortality among patients with left-sided infective endocarditis. METHODS AND RESULTS:A total of 546 consecutive patie...

journal_title：Circulation

authors： Tleyjeh IM,Ghomrawi HM,Steckelberg JM,Hoskin TL,Mirzoyev Z,Anavekar NS,Enders F,Moustafa S,Mookadam F,Huskins WC,Wilson WR,Baddour LM

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:Recurrent cerebrovascular events constitute an estimated 200,000 of the 700,000 strokes reported annually in the United States, which makes secondary stroke prevention an important goal in the management of disease among patients who have experienced stroke or transient ischemic attack. METHODS AND RESULTS:...

journal_title：Circulation

authors： Liao JK

更新日期：2007-03-27 00:00:00

abstract：BACKGROUND:Patients with diabetes mellitus (DM) are at high risk of developing congestive heart failure (CHF). However, the relationships between glucose levels and CHF in people with or without a history of DM have not been well characterized. METHODS AND RESULTS:We evaluated the associations between fasting plasma g...

journal_title：Circulation

authors： Held C,Gerstein HC,Yusuf S,Zhao F,Hilbrich L,Anderson C,Sleight P,Teo K,ONTARGET\/TRANSCEND Investigators.

更新日期：2007-03-20 00:00:00

abstract：BACKGROUND:The outcome of resuscitated patients after cardiac arrest complicating acute myocardial infarction remains poor, primarily because of the relatively low success rates of cardiopulmonary resuscitation management. Existing data suggest potential beneficial effects of early myocardial reperfusion, but the predi...

journal_title：Circulation

authors： Garot P,Lefevre T,Eltchaninoff H,Morice MC,Tamion F,Abry B,Lesault PF,Le Tarnec JY,Pouges C,Margenet A,Monchi M,Laurent I,Dumas P,Garot J,Louvard Y

更新日期：2007-03-20 00:00:00

abstract：BACKGROUND:Chagas heart disease is a frequent cause of morbidity and mortality in Latin America. Echocardiography provides useful diagnostic and prognostic information and is an important tool in the management of patients with Chagas disease. METHODS AND RESULTS:A search for relevant publications was obtained from ME...

journal_title：Circulation

authors： Acquatella H

更新日期：2007-03-06 00:00:00

abstract：BACKGROUND:Current information on the epidemiology and outcomes of hypertrophic cardiomyopathy (HCM) in children is limited by disease diversity and small case series. METHODS AND RESULTS:The Pediatric Cardiomyopathy Registry has collected prospective and retrospective data on children diagnosed with HCM since 1990. W...

journal_title：Circulation

authors： Colan SD,Lipshultz SE,Lowe AM,Sleeper LA,Messere J,Cox GF,Lurie PR,Orav EJ,Towbin JA

更新日期：2007-02-13 00:00:00

abstract：BACKGROUND:Health-related quality-of-life instruments have become important measures of early health outcomes after cardiac surgery. The relationship between quality of life after recovery from surgery and subsequent long-term survival has not previously been explored. Our objective was to determine whether the Duke Ac...

journal_title：Circulation

authors： Koch CG,Li L,Lauer M,Sabik J,Starr NJ,Blackstone EH

更新日期：2007-02-13 00:00:00